... active site and a DNA binding motif (helix-3-turn-helix) (32). Similarly, the opposite α-helical bundle (αb2) has also been observed to interact with DNA (35).
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What is the function of flap endonuclease in DNA replication?
What is the function of flap endonuclease in NHEJ?
Is FEN1 an endonuclease or exonuclease?
How does FEN1 work?
Flap endonuclease (FEN1), essential for DNA replication and repair, removes RNA and DNA 5′ flaps. FEN1 5′ nuclease superfamily members acting in nucleotide ...
... complex with product 5 ... Functional Keywords, helix-3 turn-helix, hydrophobic wedge, 3' flap ... 5' nuclease, human, long patch base excision repair, hydrolase/ ...
The protein-substrate and protein-product complexes show that most of the binding surface is to the two dsDNA regions. The upstream dsDNA is bent at ...
Flap endonuclease (FEN-1) removes 5′ overhanging flaps in DNA repair and processes the 5′ ends of Okazaki fragments in lagging strand DNA synthesis.
Jun 27, 2017 · FEN1 binding to dsDNA is mediated by four regions: (1) a hydrophobic wedge (composed of helix 2 and helix 2–3 loop) and β pin (formed between β ...
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated ...
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FEN-1 binds the unpaired 3′ DNA end (3′ flap), opens and kinks the DNA, and promotes conformational closing of a flexible helical clamp to facilitate 5′ ...
Nov 26, 2013 · Bacteriophage T7 gene 6 protein (gp6)2 is an exonuclease that hydrolyzes duplex DNA non-processively in a 5 to 3 direction and liberates ...
Yes, I assumed you meant HTH DNA binding domain, not protein. It is just a motif, not a function. Similar, but unrelated question (probably belongs in another ...
Missing: Flap Site- Repair| Flap- Dsdna
Jun 17, 2021 · To prevent fraying close to the binding sites, the DNA sequence was extended from 21 base pairs to 26 base pairs at the two ends using 3DNA (45) ...